Neferkitty was a High Priestess for the cat god Cat-Ra. She was very ambitious of power, since they once controlled humanity. Eventually humans rebelled against them and they were banished through a magical portal.
In the episode Garfield and Odie entered the portal where they were proclaimed pharaohs of Egypt. After escaping with Garfield and Odie, Neferkitty was taken by Liz's niece Heather Wilson, who calls Neferkitty "Fuzzbutton".
She returned in Revenge of The Cat People when Jon fixed the magic mirror, and she gained her followers and magic staff and began turning people into stone. But she was stopped by Garfield and Odie and sent back to Heather.
Neferkitty bears some resemblances to Arlene, but their personalities are completely different.
Her name is a play on Nefertiti, the Great Royal Wife (that is, queen consort) to the pharaoh Ahkenaten.