Neferkitty was a High Priestess for the cat god Cat-Ra. She was very ambitious and wanted power, since they had once controlled humanity. The humans, having rebelled against them, banished them through a magical portal. Odie licked the portal, which Liz Wilson brought as a gift thinking it was mirror for Jon Arbuckle, on her trip to Egypt. Garfield and Odie entered the portal where they were proclaimed pharaohs of Egypt. After willingly escaping with Garfield and Odie, Neferkitty was taken by Liz's niece Heather Wilson and renamed "Fuzzbutton". She returned when Jon fixed the magic mirror, and she gained her followers and magic staff and began turning people into stone. She was stopped by Garfield and Odie and sent back to Heather.
Neferkitty is shaped similarly to Arlene. She has blue fur, purple eyeshadow, purple lips, golden claws. She wears a lot of Egyptian jewelry. Without her jewelry, she looks like a normal cat. She can be seen with a scepter in her hand.
Neferkitty is shown to be very evil, wanting full domination on humans and the Earth and believing herself to be the best sorceress. She does not like people believing to be rude. She hates Garfield and Odie when they try and stop her. The thing she hates being called most is Fuzzbutton. She always vows vengeance.
- Neferkitty bears some physical resemblances to Arlene, although their personalities and colors are different.
- Her name is a play on Nefertiti, the wife of Akhenaten.
- Her storyboard design wore a wig and had less jewelry.