- December 1, 1980: (Start of Garfield's bored week.)
- December 2, 1980:
- December 3, 1980:
- December 4, 1980:
- December 5, 1980:
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- December 6, 1980:
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- December 7, 1980:
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- December 8, 1980: (End of Garfield's bored week.)
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- December 9, 1980: (The start of storyline about Jon planning to declaw Garfield for the second time.)
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- December 10, 1980:
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- December 11, 1980:
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- December 12, 1980:
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- December 13, 1980: (The end of storyline about Jon planning to declaw Garfield for the second time.)
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- December 14, 1980:
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- December 15, 1980:
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- December 16, 1980:
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- December 17, 1980: (The first appearance of Arlene and the start of an "Arlene week".)
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- December 18, 1980:
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- December 19, 1980:
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- December 20, 1980: (End of an "Arlene week".)
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- December 21, 1980: (The first atypical size Garfield comic strip.)
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- December 22, 1980:
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- December 23, 1980:
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- December 24, 1980: (The start of Christmas comics.)
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- December 25, 1980: (Christmas Day and the end of the Christmas comics.)
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- December 26, 1980:
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- December 27, 1980:
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- December 28, 1980: (Most of the strips dialogue is used in Here Comes Garfield.)
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- December 29, 1980:
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- December 30, 1980:
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- December 31, 1980: (The last comic strip of 1980.)
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| ← Garfield, November 1980 | Garfield, January 1981 → |
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