The "Weakest Brain" Hostess (voiced by Tress MacNeille) is the hostess of a game show called "The Weakest Brain".
Facially, the hostess has short, honey colored hair and singular eyelashes while she wears round glasses, red hooped earrings and red lipstick. She wears a black jacket with white rims and golden buttons, a black skirt and black kitty heels.
Portrayed as a stereotypical game show host, she is shown to be judgmental and does not show emotion or mercy.
- Home for the Holidays
- Ticket to Riches
- The Art of Being Uncute
- Night of the Bunny Slippers
- Cyber Mailman
- Planet of Poultry
- Inside Eddie Gourmand
- The Bluebird of Happiness
- Her likeness and occupation are reminiscent of Anne Robinson, the host of British game show "The Weakest Link".